A Photocatalytic Regioselective Direct Hydroaminoalkylation of Aryl-Substituted Alkenes with Amines
نویسندگان
چکیده
A photocatalytic method for the α-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves regioselective addition α-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to α-position unsaturated esters. scope aromatic alkenes was extended styrenes undergoing with anti-Markovnikov selectivity, which confirms importance group at β-position. Simple scale-up is demonstrated under continuous flow conditions, highlighting practicality method.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c01715